A beautiful young woman with unusually big thumbs, Sissy Hankshaw decides, fittingly enough, to become a hitchhiker. After finding work as a model for feminine products, Sissy goes to shoot an ad at the Rubber Rose, a ranch owned by the Countess, the company's flamboyant cross-dressing head. While at the ranch, Sissy meets numerous other eccentric characters, including an outgoing and rebellious cowgirl named Bonanza Jellybean.
